Table A7:
Input Parameters Used for Probabilistic Sensitivity Analysis
| Model Parameter | Mean (SE) | Distribution | Reference |
|---|---|---|---|
| Monthly probabilities and rates | |||
| Probability of nonadherence: | |||
| High pressure (25–35 mm Hg) | 0.009 (0.008) | Beta | Nelson et al, 200627 |
| Low pressure (18–24 mm Hg) | 0.005 (0.006) | Beta | Nelson et al, 200627 |
| Support (14–17 mm Hg) | 0.0005 (0.0002) | Beta | Nelson et al, 200627 |
| Probability of ulcer recurrence, compression stockings: | |||
| High pressure (25–35 mm Hg) | 0.006 (0.0065) | Beta | Nelson et al, 200627 |
| Low pressure (18–24 mm Hg) | 0.008 (0.0073) | Beta | Nelson et al, 200627 |
| Support (14–17 mm Hg) | 0.010 (0.0097) | Beta | Assumption |
| Risk of ulcer recurrence: | |||
| Compression stockings vs. no compression stockings | 2.30 (0.24) | Log-normal | Vandongen & Stacey, 200028 |
| Ulcer healing with compression bandages | 0.163 (0.0179) | Beta | Pham et al, 201240 |
| Infection rate | 0.05 (0.0358) | Beta | Carter et al, 201449 |
| Utilities | |||
| Recurred ulcer | 0.77 (0.0086) | Beta | Pham et al, 201240 |
| Healed ulcer | 0.87 (0.0055) | Beta | Pham et al, 201240 |
| Infected ulcer | 0.77 (0.0086) | Beta | Assumption |
| Costs | |||
| Healed ulcer health state, high pressure (25–35 mm Hg) | 26.1 (6.5) | Gamma | Calculation |
| Healed ulcer health state, low pressure (18–24 mm Hg) | 22.2 (5.6) | Gamma | Calculation |
| Healed ulcer health state, support (13–17 mm Hg) | 13.8 (3.5) | Gamma | Calculation |
| Healed ulcer health state, no compression stockings, $a | 5.5 (1.4) | Gamma | Calculation |
| Recurred ulcer health state,a | 128 (32.0) | Gamma | Pham et al, 201240 |
| Infected ulcer health state, $a | 222.9 (55.7) | Gamma | Calculation |
Abbreviation: SE, standard error.
a
All costs given in 2018 Canadian dollars.