Table 11:

Health State Utilities Considered for the Economic Model

Model Parameter: Utilities	Mean (SD/SE/95% CI)a	Source
Treated major depression		Schaffer et al, 2002102
Mild MDE	0.79 (SD: 0.28)
Moderate MDE	0.67 (SD: 0.36)
Unguided iCBT, major depression/anxiety
Unguided iCBT vs. usual care	–0.01 (–0.06 to 0.09)	Duarte, 2017,37 Littlewood, 201536
Guided iCBT, major depression, at 12 mo	0.84 (0.81 to 0.86)	Duarte, 2017,37 Littlewood, 201536
Guided iCBT, anxiety		Hedman et al, 201158,104
Baseline	0.77 (SD: 0.18)
4 mo	0.82 (SD: 0.14)
6–12 mo	0.85 (SD: 0.14)
Utility at 12 mo	0.83 (0.81 to 0.84)
Individual face-to-face CBT, major depression/anxiety		King et al, 2000103
Baseline	0.73
4 mo	0.85 (NR)
12 mo	0.85 (NR)
Utility at 12 mo	0.83b
Group CBT, major depression/anxietyc		Hedman et al, 201158,104
Baseline, usual care	0.74 (SD: 0.19)
4 mo	0.80 (SD: 0.17)
6–12 mo	0.81 (SD: 0.17)
Utility at 12 mo	0.80 (0.77–0.82)
Normal health, well health state	0.94 (SE: 0.03)	Lenert et al (2000)105

Abbreviations: CBT, cognitive behavioural therapy; CI, confidence interval; iCBT, internet-delivered CBT; MDE, major depressive episode; NR, not reported; SD, standard deviation; SE, standard error.

^aBeta distributions assigned in probabilistic sensitivity analysis (please see above formulas for calculations of the beta distribution's parameters: α and β.

^bStandard error assumed to be the same as the one estimated for the group CBT.

^cAssumed to be the same for anxiety disorders and major depression, based on results of a study in patients with social anxiety disorder.