Table 2:
Summary of Results of Included Systematic Reviews for Mild to Moderate Major Depression
| Author, Year | No. of Studies/No. of Participants | Results | Quality Assessment |
|---|---|---|---|
| Guided internet-deliverd CBT compared with waiting list | |||
| Symptoms and Response to Treatment | |||
| Arnberg et al, 201420 | 5 RCTs/159 | SMD = 0.83 (95% CI 0.59–1.07) | GRADE: ⊕⊕⊕ moderate |
| Internet-delivered CBT compared with weekly telephone calls | |||
| Symptoms and Response to Treatment | |||
| Kaltenthaler et al, 200822 | 1 RCT/525 | SMD = 3.2 (95% CI 0.9–5.4) | CASP Tool Randomization method: statistical software program used Masking: no maskedAssessment Power calculation: yes Loss to follow-up loss: number and some reasonsreported |
| Patient Dropout and Treatment Adherence | |||
| Kaltenthaler et al, 200822 | 1 RCT/525 | 25.3% of participants dropped out of the iCBT program;10% of participants dropped out from the control group, who received weekly telephone calls | CASP Tool Randomization method: statistical software program used Masking: no masked assessment Power calculation: yes Loss to follow-up loss: number and some reasons reported |
| Internet-delivered CBT compared with usual care | |||
| Symptoms and Response to Treatment | |||
| Kaltenthaler et al, 200822 | 1 RCT/274 | iCBT vs. usual care 3 mos: −4.3 (95% CI not reported)a 5 mos: −3.9 (95% CI not reported)a 8 mos: −5.9 (95% CI not reported)a |
CASP Tool Randomization: sealed envelopes, stratified for medication and duration of current episode Masking: no masked assessment Power calculation: yes Loss to follow-up: number and some reasons reported |
| Patient Dropout and Treatment Adherence | |||
| Kaltenthaler et al, 200822 | 1 RCT/274 | 35% dropped out during the study | CASP Tool Randomization: SPSS function Masking: no masked assessment Power calculation: yes Loss to follow-up: loss and reasons reported |
Abbreviations: CI, confidence interval; iCBT, internet-delivered cognitive behavioural therapy; SMD, standardized mean difference.
a
A positive improvement in symptoms in favour of iCBT. The mean differences were calculated by the authors of the health technology assessment.