Table A2:
Assessment of the Applicability of Studies Assessing the Cost-Effectiveness of iCBT for Major Depression
| Author, Year, Country | Is the study population similar to the question? | Are the interventions similar to the question? | Is the health care system in which the study was conducted sufficiently similar to the Ontario context? | Were the perspectives clearly stated? What were they? | Are estimates of relative treatment effect from the best available source? |
|---|---|---|---|---|---|
| Duarte et al, 2017,37 Littlewood, et al, 2015,36 United Kingdom | Yes | Yes, iCBT plus usual care (drug allowed) vs usual care, low-guided | No | Yes, NHS | Unclear |
| Romero-Sanchiz et al, 2017,43 Spain | Yes | Yes, unguided/guided vs TAU | No | Yes, Spain, societal | Unclear |
| Lee et al, 2017,49 Australia | Yes | Partially | No | Yes, health care payer | Unclear |
| Brabyn et al, 2016,38 United Kingdom | Yes | Partially | No | Yes, NHS and PPS | Unclear |
| Dixon et al, 2016,39 United Kingdom | Yes | Partially | No | Yes, NHS and PPS | Unclear |
| Solomon et al, 2015,48 Australia | Yes | Partially | No | No, health care payer | Unclear |
| Titov et al, 2015,44 Australia | Yes | Partially | No | No, health care payer | Unclear |
| Gerhards et al, 2015,45 Netherlands | Yes | Partially | No | Yes, employer and societal | Unclear |
| Phillips et al, 2014,41 United Kingdom | Partially | Partially | No | Yes, societal | Unclear |
| Gerhards et al, 2010,46 Netherlands | Yes | Partially | No | Yes, societal | Unclear |
| Warmerdam et al, 2010,47 Netherlands | Yes | Partially | No | Yes, societal | Unclear |
| Hollinghurst et al, 2010,40 United Kingdom | Yes | Partially | No | Yes, societal | Unclear |
| Kaltenthaler et al, 2006,50 United Kingdom | Yes | Partially | No | Yes, NHS | Unclear |
| McCrone et al, 2004,42 United Kingdom | Partially | Partially | No | Yes, NHS | Unclear |
| Author, Year, Country | Are all future costs and outcomes discounted? (If yes, at what rate?) | Is the value of health effects expressed in terms of quality-adjusted life-years? | Are costs and outcomes from other sectors fully and appropriately measured and valued? | Overall judgement (directly applicable/partially applicable/not applicable) |
|---|---|---|---|---|
| Duarte et al, 2017,37 Littlewood, et al, 2015,36 United Kingdom | Yes (3.5%) | Yes | Yes, microcosting approach accounting for cost of CBT, medications, health and social care services | Partially applicable |
| Romero-Sanchiz et al, 2017,43 Spain | No, 12 mo, NA | Yes | Yes, microcosting approach accounting for both direct and indirect costs | Partially applicable |
| Lee et al, 2017,49 Australia | No, 12 mo, NA | Yes | Yes | Partially applicable |
| Brabyn et al, 2016,38 United Kingdom | No, 12 mo, NA | Yes | Yes | Partially applicable |
| Dixon et al, 2016,39 United Kingdom | No, 12 mo, NA | Yes | Yes | Partially applicable |
| Solomon et al, 2015,48 Australia | No, 6 mo, NA | Yes | Partially | Partially applicable |
| Titov et al, 2015,44 Australia | No, 8 wk, NA | Yes | Partially | Partially applicable |
| Gerhards et al, 2015,45 Netherlands | No, 12 mo, NA | Yes | Partially | Partially applicable |
| Phillips et al, 2014,41 United Kingdom | No, 12 mo, NA | Yes | Yes | Partially applicable |
| Gerhards et al, 2010,46 Netherlands | No, 12 mo, NA | Yes | Yes | Partially applicable |
| Warmerdam et al, 2010,47 Netherlands | No, 12 wk, NA | Yes | Unclear | Partially applicable |
| Hollinghurst et al, 2010,40 United Kingdom | No, 8 mo, NA | Yes | Unclear | Partially applicable |
| Kaltenthaler et al, 2006,50 United Kingdom | No, 18 mo, NA | Yes | Yes | Partially applicable |
| McCrone et al, 2004,42 United Kingdom | No, 8 mo, NA | No | Yes | Partially applicable |
Abbreviations: CBT, cognitive-behavioural therapy; iCBT, internet-delivered CBT; NA, not applicable; NHS, National Health Service; PPS, personal social services; TAU, treatment as usual.