Table A8:
Efficacy Estimates Used in the Economic Model: Risk of Recurrence
| Model Parameter | Relative Risk (95% CI) | Distribution | Source |
|---|---|---|---|
| Risk of recurrence, major depression: CBT only vs no treatment | 0.68 (0.53–0.76) | Normal (log-odds ratio) | Biesheuvel-Leliefeld et al, 201596 |
| Risk of recurrence, major depression: CBT plus pharmacotherapy vs pharmacotherapy only | 0.94a (0.72–1.21) | Normal (log-odds ratio) | Amick et al, 2015150 |
| Risk of recurrence, major depression: Individual CBT vs group CBT | 0.78b (0.69–0.93) | Normal (log-odds ratio) | Churchill et al, 200197 |
| Risk of recurrence, major depression: Guided iCBT vs usual care | 0.67 (0.54–0.83) | Normal (log-odds ratio) | Andrews et al, 201821 |
| Risk of recurrence, second-generation antidepressant, sertraline | 0.80 (0.69–0.93) | Normal (log-odds ratio) | Cipriani et al, 2009151 |
Abbreviations: CBT, cognitive behavioural therapy, relates to face-to-face CBT; CI, confidence interval; iCBT, internet-delivered CBT.
a
Recalculated from the reported relative risk of 1.06 (95% CI 0.82–1.38).
b
Relative risk estimated from the odds ratio after accounting for a mean baseline probability of major depressive episode in the placebo arm of 0.57.152