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. 2018 Nov 24;76(5):903–920. doi: 10.1007/s00018-018-2971-0

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Members of the miR-15/107 microRNA family. a 10 microRNAs sharing “AGCAGC” within the “seed” region. b A phylogenetic tree of miR-15/107 family members from Homo sapiens (hsa), Monodelphis domestica (mdo), Macaca mulatta (mml), Mus musculus (mmu), Ornithorhynchus anatinus (oan), Gallus gallus (gga) and Xenopus tropicalis (xtr). miR-103 and -107 are the least closely related, and omitted in the plot. miR-424(322) is most closely related to miR-15c in mdo, oan, gga and xtr, while miR-503 is most closely related to miR-16c in gga, oan and xtr