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Markov model structure i disease stages I, II, III, or IV. Prssi probability of remaining in “stable” state (Stage i), Pdssi probability of dying in “stable” state (Stage i), Ppssi probability to progress from “stable” state (Stage i), Prpsi probability of remaining in “post-progression” state (Stage i), and Pdpsi probability of dying in “post-progression” state (Stage i)
