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. 2018 Jul 16;56(3):2278–2299. doi: 10.1007/s12035-018-1223-5

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — A diagrammatic representation of the interaction between various VGICs and receptors present on the plasma membrane with the calcium handling mechanisms on the ER membrane. Thick arrows depict the functional interactions between the connecting molecules. Thin arrows point to the flux of calcium ions through various channels and receptors. SERCA, sarcoplasmic endoplasmic reticulum ATP-ase pump; SOCC, store-operated calcium channels; PKA, protein kinase A; RyR, ryanodine receptor. Based on data from [17, 156, 158]