Fig. 1.

Performance of modulator of apoptosis 1 (MOAP-1)^−/− (KO) and wild-type control (WT) mice (age 3–6 months) in various behavioral tests. a Western blot showing a lack of MOAP-1 protein expression in the cerebral cortex of MOAP-1^−/− mice. b Immobility time in the forced swimming test (FST), n = 15–17. c Immobility time in the tail suspension test (TST), n = 15–18. d Fall latency in the rotarod test, n = 14. e Total number of arm entries and time spent in open arms on the elevated plus maze (EPM), n = 10. f Total distance traveled and time spent in the center zone in the open field test (OFT), n = 10–12. g Time spent in bright zone in the light dark box (LDB), n = 15. Data are presented as mean ± SEM. Total trial time was 4 min for FST, 10 min for OFT, and 5 min for all others. *P < 0.05, **P < 0.01 against WT by independent two-tailed t test