Table 1.
Pathway enrichment analysis of reverse synthetic lethal gene families
| Enrichment score | UniProt keywords or sequence features | Adj. p value |
|---|---|---|
| 14.88 | Protein phosphatase | 4.2E−38 |
| 14.33 | G-protein coupled receptor | 1.2E−17 |
| Receptor | 2.5E−17 | |
| 10.93 | Ion channel | 3E−18 |
| Ion transport | 1.4E−10 | |
| 10.55 | Receptor | 2.5E−17 |
| Glycoprotein | 1E−11 | |
| 9.34 | Ribonucleoprotein | 3E−11 |
| Ribosomal protein | 9.4E−10 | |
| 9.04 | Glycoprotein | 1E−11 |
| Disulfide bond | 7.3E−11 | |
| 5.2 | Spliceosome | 1.3E−07 |
| mRNA splicing | 3.5E−06 | |
| 4.63 | Metal ion-binding site: manganese 1; via carbonyl | 6.3E−03 |
| Manganese | 2.2E−01 | |
| 4.46 | Protease | 3.5E−06 |
| Zymogen | 1.5E−05 | |
| 4.06 | Metal ion-binding site: iron | 8.3E−01 |
| Metal ion-binding site: manganese | 9.8E−01 | |
| 4.01 | Palmitate | 1.8E−03 |
| Lipoprotein | 4.7E−02 | |
| 4.00 | Threonine protease | 1.0E−06 |
| Proteasome | 1.1E−04 |
The most significant UniProt Keywords for each enrichment cluster from a DAVID ontology analysis of genes with a CDH1−/−/MCF10A viability ratio ≥ 1.3 are shown. Where no UniProt Keyword was listed, the UniProt Sequence Feature was used