Table 2.
Gastric cancer pathways significantly associated with E-cadherin synthetic lethality
| Reactome ID | Reactome pathway | Gene numbera | FDR-adjusted P value |
|---|---|---|---|
| R-HSA-421270 | Cell–cell junction organisation | 64 | 0.0168 |
| R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins | 11 | 0.0168 |
| R-HSA-1500931 | Cell–cell communication | 129 | 0.0228 |
| R-HSA-164940 | Nef-mediated downregulation of MHC class I complex cell surface expression | 9 | 0.0228 |
| R-HSA-5653656 | Vesicle-mediated transport | 674 | 0.0228 |
| R-HSA-199991 | Membrane trafficking | 635 | 0.0228 |
| R-HSA-428157 | Sphingolipid metabolism | 90 | 0.0315 |
| R-HSA-446728 | Cell junction organisation | 91 | 0.0315 |
| R-HSA-418990 | Adherens junctions interactions | 33 | 0.0315 |
| R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus | 31 | 0.0315 |
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | 38 | 0.0315 |
| R-HSA-1660661 | Sphingolipid de novo biosynthesis | 44 | 0.1146 |
| R-HSA-199977 | ER to Golgi Anterograde Transport | 154 | 0.1442 |
| R-HSA-500792 | GPCR ligand binding | 451 | 0.1453 |
| R-HSA-975576 | N-glycan antennae elongation in the medial/trans-Golgi | 26 | 0.1453 |
| R-HSA-8852405 | Signalling by MST1 | 5 | 0.1669 |
| R-HSA-420029 | Tight junction interactions | 29 | 0.1842 |
| R-HSA-8850843 | Phosphate bond hydrolysis by NTPDase proteins | 8 | 0.197 |
| R-HSA-211859 | Biological oxidations | 218 | 0.197 |
| R-HSA-1483257 | Phospholipid metabolism | 210 | 0.197 |
aThe number of genes in the pathway that were represented in the TCGA data