Figure 5:

Estimation of time to proton density fat fraction (PDFF) normalization, with the upper limit of normal PDFF for liver defined as 5%. Time 0 corresponds to baseline visit. Mixed-effects linear regression modeling of natural log-transformed PDFF (y-axis) as a function of time (x-axis) demonstrates a mean time to normalization (the point where the natural log-transformed trajectory crosses the ln [5%] = 1.6% line) of 22.5 weeks. Trajectories have been extended (dashed lines) for 13 participants for whom the estimated crossing time occurs outside the observation window. Of note, in this sample it was estimated that 90% of study participants achieved normal PDFF of 5% by 42 weeks.