Fig. 6.

—The Esc1 conserved motifs. Multiple alignment of the Esc1 conserved motifs (A–E). In the alignments, positions conserved over the family are colored in green for hydrophobic amino acids (V, I, L, F, M, Y, W), light green for amino acids that can substitute for hydrophobic amino acids in a context-dependent way (A, T, S, C), orange for aromatic amino acids (F, Y, W), gray for small amino acids (G, V, A, S, T), yellow for P, blue for basic (K, R, H) amino acids, and pink for acidic (D, E, Q, N, S, T) amino acids. Domain limits (in brackets) are reported at the end of the sequences, and the UniProt identifiers of the sequences are reported in supplementary table S1, Supplementary Material online.