4.

Trial sequential analysis for the comparison PEI versus PAI on survival in people with early hepatocellular carcinoma. The diversity‐adjusted required information size (DARIS) was calculated based upon a proportion of deaths of 23% in the percutaneous ethanol injection (PEI) group; a relative risk reduction (RRR) of 20%; an alpha of 5% and a beta of 20%. The cumulative Z‐score did not cross the monitoring boundary and did not reach the monitoring boundary for futility. Therefore, further randomised trials are needed.