Fig. 11.

a The simulated compound action potential in the cuff medium approaches the experimental recording well in the relevant signal segments. As expected, homogeneous and radially inhomogeneous media lead to much weaker signal amplitudes. For the experimental recording, the grey underlying area indicates the standard deviation over the 10 stimulation repetitions. See Table 2 for axon properties. Distance between stimulation site and bipolar electrode (3 mm pole distance, 235 μ m radius) was 8 cm. All axons were activated by intracellular stimulation. The timing of unmyelinated SFAPs was adapted to regular conduction velocity values assumed in mammalian peripheral nerves (CV $=1.4\cdot \sqrt{d}$, CV in ms^− 1, d in μ m). b The signal from myelinated fibres, which arrive first, appears similar to the experiment. c The unmyelinated signal segment matches the amplitude and duration of the experimental recording as well. The signal-to-noise ratio of the recordings is much worse for unmyelinated fibres, however, as the amplitude of their SFAPs is low