Table 2.

Multivariable analysis^a of clinical response, controlling for clinical factors (N = 281)

Variable	Odd ratio (95% CI)	p value*
Recurrence Score result (per 50-unit increaseb)	0.06 (0.02, 0.18)	< 0.001
Age (years)	1.00 (0.96, 1.05)	0.854
Baseline tumor size (mm)	1.00 (0.96, 1.03)	0.786
Grade
1 versus 3	0.44 (0.17, 1.09)	0.074
2 versus 3	0.81 (0.29, 2.19)	0.671

CI confidence interval

*p value based on the profile likelihood test

^aESR1, PGR, and ER gene-group were not included in the prespecified multivariable analysis because they represent individual gene components of the Recurrence Score algorithm

^bStatistics were calculated per 50-unit change in Recurrence Score result to facilitate comparison with results of the original validation studies