Table 3.

Multivariable analysis of clinical response, controlling for clinical factors (N = 281)

Model	Variable	Odds ratio (95% CI)	p value*
1	ESR1 by RT-PCR (standardized)	1.29 (1.00, 1.68)	0.047
	Age (years)	1.02 (0.97, 1.06)	0.470
	Baseline tumor size (mm)	0.99 (0.96, 1.03)	0.696
	Grade
	1 versus 3	0.76 (0.33, 1.76)	0.522
	2 versus 3	0.99 (0.38, 2.54)	0.981
2	PGR by RT-PCR (standardized)	1.98 (1.52, 2.63)	< 0.001
	Age (years)	1.01 (0.96, 1.05)	0.803
	Baseline tumor size (mm)	1.00 (0.96, 1.04)	0.976
	Grade
	1 versus 3	0.77 (0.32, 1.83)	0.545
	2 versus 3	1.17 (0.44, 3.12)	0.758
3	ER gene-group score (standardized)	2.05 (1.54, 2.78)	< 0.001
	Age (years)	1.01 (0.96, 1.05)	0.755
	Baseline tumor size (mm)	1.00 (0.97, 1.04)	0.874
	Grade
	1 versus 3	0.57 (0.24, 1.38)	0.216
	2 versus 3	0.86 (0.32, 2.30)	0.759

CI confidence interval, ER estrogen receptor, RT-PCR reverse transcription-polymerase chain reaction

*p value based on the profile likelihood test