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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: J Struct Biol. 2018 Aug 7;204(2):319–328. doi: 10.1016/j.jsb.2018.08.003

Fig. 1. A simple example of Resolution-exchange Molecular Dynamics Flexible Fitting (ReMDFF).

Fig. 1

Three replicas are included in this schematic. Each replica consists of a molecular structure and a cryo-EM map-based grid potential. Different green boxes represents grid potentials of different resolutions. The structural models as refined at different resolutions are shown in red, blue, and yellow with different hue levels representing changes in the conformation. The arrows indicate the transfer of a grid potential from one replica to another. The output structure is selected from the trajectory visited by the grid potential of the original resolution (dark green).