Figure 2:
Infection with ZIKV in the presence of mAb 33.3A06 results in increased viral binding and entry of HCs. A) Binding/entry assay schematic. EM4CO4 and 33.3A06 mAbs were used at 0.4 µg/mL. B) ZIKV RNA from bound virus (top) or internalized virus (bottom) was measured by qRT-PCR. Representative experiment from n=2 donors (biological triplicates ±SD). Data were analyzed by 1-way ANOVA and Tukey’s multiple comparison test, **p<0.01, ***p<0.001, ****p<0.0001.