Table 3.
Age*Time | Hypertension*Time | Obesity*Time | APOE e4 Carrier Status*Time |
HDL Cholesterol*Time | Race*Time | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Brain Regions of Interest |
β | SE | p- value |
β | SE | p- value |
β | SE | p- value |
β | SE | p- value |
β | SE | p- value |
β | SE | p- value |
Whole Brain | −0.0375 | 0.0204 | 0.066 | −0.8075 | 0.3236 | 0.013 | −0.2374 | 0.2302 | 0.303 | −0.2334 | 0.3305 | 0.480 | −0.0048 | 0.0103 | 0.642 | −0.7118 | 0.3981 | 0.074 |
Gray Matter | −0.0745 | 0.0164 | <0.001 | −0.4890 | 0.2601 | 0.060 | −0.1631 | 0.1872 | 0.383 | −0.1753 | 0.2651 | 0.508 | 0.0012 | 0.0082 | 0.885 | −0.6076 | 0.3193 | 0.057 |
White Matter | 0.0091 | 0.0090 | 0.312 | −0.3045 | 0.1419 | 0.032 | −0.0045 | 0.1056 | 0.966 | −0.0620 | 0.1443 | 0.667 | −0.0020 | 0.0045 | 0.664 | −0.2345 | 0.1751 | 0.180 |
Ventricles | 0.0340 | 0.0067 | <0.001 | −0.0174 | 0.1141 | 0.879 | −0.0235 | 0.0417 | 0.573 | 0.1156 | 0.1192 | 0.332 | −0.0037 | 0.0034 | 0.269 | 0.2370 | 0.1295 | 0.067 |
Amygdala | −0.0005 | 0.0001 | <0.001 | 0.0001 | 0.0021 | 0.959 | 0.0010 | 0.0013 | 0.404 | −0.0042 | 0.0021 | 0.050 | 0.0001 | 0.0001 | 0.300 | −0.0004 | 0.0025 | 0.881 |
Hippocampus | −0.0018 | 0.0003 | <0.001 | 0.0042 | 0.0046 | 0.363 | 0.0023 | 0.0030 | 0.444 | −0.0130 | 0.0048 | 0.007 | 0.0001 | 0.0001 | 0.636 | −0.0143 | 0.0057 | 0.012 |
Entorhinal Cortex | −0.0008 | 0.0003 | 0.016 | 0.0005 | 0.0051 | 0.925 | 0.0012 | 0.0035 | 0.730 | −0.0042 | 0.0052 | 0.428 | 0.0003 | 0.0002 | 0.045 | −0.0119 | 0.0062 | 0.057 |
Parahippocampal Gyrus | −0.0012 | 0.0003 | <0.001 | 0.0038 | 0.0052 | 0.465 | 0.0013 | 0.0037 | 0.719 | −0.0021 | 0.0053 | 0.695 | 0.0004 | 0.0002 | 0.030 | −0.0142 | 0.0063 | 0.025 |
Orbitofrontal Cortex | −0.0019 | 0.0007 | 0.004 | −0.0208 | 0.0105 | 0.047 | 0.0026 | 0.0084 | 0.753 | −0.0025 | 0.0105 | 0.813 | −0.0001 | 0.0003 | 0.871 | −0.0299 | 0.0129 | 0.021 |
Superior Temporal Gyrus | −0.0010 | 0.0005 | 0.033 | −0.0062 | 0.0074 | 0.407 | −0.0047 | 0.0061 | 0.442 | −0.0016 | 0.0074 | 0.828 | 0.0000 | 0.0002 | 0.970 | −0.0166 | 0.0092 | 0.069 |
Middle Temporal Gyrus | −0.0042 | 0.0011 | <0.001 | −0.0186 | 0.0180 | 0.303 | 0.0008 | 0.0133 | 0.953 | 0.0028 | 0.0183 | 0.881 | −0.0002 | 0.0006 | 0.728 | −0.0557 | 0.0222 | 0.012 |
Inferior Temporal Gyrus | −0.0045 | 0.0010 | <0.001 | −0.0193 | 0.0154 | 0.211 | 0.0130 | 0.0120 | 0.279 | −0.0045 | 0.0155 | 0.773 | −0.0003 | 0.0005 | 0.600 | −0.0603 | 0.0189 | 0.001 |
Fusiform | −0.0020 | 0.0007 | 0.004 | −0.0023 | 0.0110 | 0.834 | 0.0019 | 0.0077 | 0.808 | −0.0126 | 0.0112 | 0.261 | 0.0001 | 0.0003 | 0.771 | −0.0252 | 0.0135 | 0.061 |
SE – standard error, Note: All bolded values mean p<0.05. Linear mixed-effects models included each predictor and an interaction with that predictor and time. These models were adjusted by baseline ICV, scan type, age, sex, diagnostic status, race, time, and two-way interactions of scan type, age, sex, diagnostic status, and race with time. Continuous variables were mean-centered.