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. 2019 Feb 25;11:1843–1855. doi: 10.2147/CMAR.S186142

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© 2019 Hatoum et al. This work is published and licensed by Dove Medical Press Limited

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A summary of proteases secretion by GBM cells and their actions upon activation.

Notes: Several positive feedback loops of activation exist. What is also evident is the extensive redundancy in the activation and upregulation of the different proteases which have overlapping functions. Research should aim to identify the factors upregulated in different subtypes of GBM to allow potential tailored treatments to different patients.

Abbreviations: ECM, extracellular matrix; GBM, glioblastoma multiforme; suPAR, soluble form of uPAR.