Table 15:
Additional Clinical Parameters
| Parameter | Mean; Distribution (Parameter 1; Parameter 2) | Sources |
|---|---|---|
| Hypothetical cohort size of target population | 145,000; uniform (142,000; 148,000) | Calculated |
| Uptake rate for prenatal screening | ||
| Traditional prenatal screening | 68%; fixed | BORN data |
| Second-tier NIPT | 68%; fixed | BORN data |
| First-tier NIPT | 68%; fixed | BORN data |
| Pregnant people who accept prenatal screening | ||
| Screening in the first trimester | 90%; fixed | BORN data |
| Screening in the second trimester | 10%; fixed | BORN data |
| Accept further testing after a positive result | ||
| Traditional prenatal screening | 60%; fixed | Huang et al, 201775; Okun et al, 201483 |
| Second-tier NIPT | 76%; fixed | BORN data |
| Diagnostic testing after positive results from traditional prenatal screening and NIPT | 95%; fixed | Estimate |
| First-tier NIPT | 85%; fixed | Estimate |
| Very-high-risk populationa | 0.6%; fixed | BORN data |
Abbreviation: NIPT, noninvasive prenatal testing.
a
Very high risk was defined as pregnant people with a trisomy 21 risk > 1/10 or nuchal translucency ≥ 3.5 mm. In the second-tier NIPT strategy, these people would receive diagnostic testing directly instead of second-tier NIPT.