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. 2019 Feb 19;19(4):1–166.

Table 16:

Cost Parameters

Parameter Cost, $ Sources
Prenatal screening
  eFTSa 124.50 Data from an Ontario hospital, 2018
  MSSb 186.75 Data from an Ontario hospital, 2018
  NIPTc    
    Trisomies 21, 18, and 13, and sex chromosome aneuploidies 390 Ministry of Health and Long-Term Care
    Inclusion of 22q11.2 deletion Extra 195 (Panorama) LifeLabs Genetics112
  NT ultrasound (for 90% people for first-tier NIPT) 59.85 Ontario Schedule of Benefits113
General assessment physician visit (e.g., to introduce prenatal screening) 77.20 Ontario Schedule of Benefits113
Genetic counselling for trisomies 21, 18, and 13
  Positive NIPT result 74.70 Ontario Schedule of Benefits113
  Negative NIPT result 37.65 Ontario Schedule of Benefits113
Additional counselling for sex chromosome aneuploidies and/or 22q11.2 deletion 74.70 Ontario Schedule of Benefits113
Amniocentesis (total) 586  
  Physician 102 Ontario Schedule of Benefits113
  Laboratory expenses, labour, and reagents 484 Lilley et al, 2017114
Chorionic villus sampling (total) 1,003  
  Physician 153 Ontario Schedule of Benefits113
  Laboratory expenses, labour, and reagents 850 Lilley et al, 2017114
Post-test physician visit for pregnant people with positive screening test results (any strategy) 74.70 Ontario Schedule of Benefits113
Physician visit for pregnant people with a confirmed affected fetus 161.15 Ontario Schedule of Benefits113
Voluntary termination of pregnancy (total) 1,308  
  Surgeon and anesthesiologist 204 Ontario Schedule of Benefits113
  Termination of pregnancy 1,104 Ontario Case Costing Initiative115
Spontaneous pregnancy loss or diagnostic testing procedure-related pregnancy loss (total) 658  
  Surgeon and anesthesiologist 204 Ontario Schedule of Benefits113
  Ambulatory care 454 Ontario Case Costing Initiative115

Abbreviations: eFTS, enhanced first-trimester screening; MSS, maternal serum screening (also known as quadruple screening); NIPT, noninvasive prenatal testing; NT, nuchal translucency.

a

eFTS includes pregnancy-associated plasma protein A, free β-human chorionic gonadotrophin, placental growth factor, α-fetoprotein, and NT ultrasound.

b

MSS (quadruple screening) includes α-fetoprotein, unconjugated estriol, free β-human chorionic gonadotrophin. and inhibin-A.

c

If NIPT fails for any reason, there are no additional costs for a repeat test. If the repeat (second) NIPT test also fails, there are no refunds for unsuccessful tests.