Table 20:

Reference Case Analysis Results, Incremental Cost, Incremental Effectiveness, and Incremental Cost per Case Detected

Comparison	Incremental Costs (95% CrI), $	Additional Cases Detected (95% CrI), n	Difference in Diagnostic Tests (95% CrI), n	Difference in Diagnostic-Procedure-Related Pregnancy Losses (95% CrI), n	Difference in Affected Live Births (95% CrI), n	Incremental Cost Per Case Detected, $
Second-tier NIPT vs. traditional prenatal screening	−830,038 (−1,502,076 to –266,284)	30 (6–56)	−2,392 (−3,275 to –1,612)	−5 (−11 to 0)	−11 (−34 to 12)	Dominant
First-tier vs. second-tier NIPT	34,636,006 (27,131,648– 42,272,116)	84 (54–117)	1,407 (1,128–1,696)	3 (−1 to 7)	−31 (−53 to –8)	411,274

Abbreviations: CrI, credible interval; NIPT, noninvasive prenatal testing.

Note: Numbers may appear inexact due to rounding.