Table 22:
Scenario Analysis Results, Increased Uptake of First-Tier NIPT
| Uptake of First-Tier NIPT | Total Costs (95% CrI), $ | Cases Detected (95% CrI), n | Diagnostic Tests Performed (95% CrI), n | Diagnostic-Procedure-Related Pregnancy Losses (95% CrI), n | Affected Live Births (95% CrI), n | Incremental Cost Per Case Detected, vs. Second-Tier NIPT,a $ |
|---|---|---|---|---|---|---|
| 80% | 70,132,717 (60,705,461–79,300,267) | All: 321 (263–400) Trisomy 21: 224 (176–286) Trisomy 18: 75 (45–116) Trisomy 13: 22 (9–42) |
2,497 (2,154–2,859) | 4 (1–9) | All: 129 (105–155) Trisomy 21: 98 (78–120) Trisomy 18: 18 (10–26) Trisomy 13: 13 (6–21) |
327,247 |
| 90% | 77,488,657 (67,296,999–87,898,000) | All: 362 (296–451) Trisomy 21: 253 (197–321) Trisomy 18: 84 (53–129) Trisomy 13: 24 (10–46) |
2,807 (2,443–3,187) | 5 (1–9) | All: 114 (92–136) Trisomy 21: 86 (68–104) Trisomy 18: 15 (8–24) Trisomy 13: 12 (5–20) |
293,134 |
| 100% | 84,473,692 (72,615,687–96,107,514) | All: 400 (326–495) Trisomy 21: 280 (220–360) Trisomy 18: 93 (58–141) Trisomy 13: 27 (12–52) |
3,124 (2,708–3,563) | 6 (2–11) | All: 98 (79–120) Trisomy 21: 74 (57–93) Trisomy 18:14 (7–21) Trisomy 13: 11 (5–19) |
273,187 |
Abbreviations: CrI, credible interval; NIPT, noninvasive prenatal screening.
Note: Numbers may appear inexact due to rounding.
a
See Table 18 (reference case) for cost and effectiveness outcomes for second-tier NIPT.