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. 2019 Feb 19;19(4):1–166.

Table 24:

Scenario Analysis Results, A Lower Trisomy 21 Risk Cutoff for Traditional Prenatal Screening in Second-Tier NIPT

Scenario Total Costs (95% CrI), $ Cases Detected (95% CrI), n Diagnostic Tests Performed (95% CrI), n Diagnostic-Procedure-Related Pregnancy Losses (95% CrI), n Affected Live Births (95% CrI), n Incremental Cost Per Case Detected, First-Tier vs. Second-Tier NIPT, $
Acceptance of further testing after a positive result from traditional prenatal screening: 76% (same as reference case) 28,949,494 (25,455,144–32,548,127) All: 195 (153–247)
Trisomy 21: 154 (117–202)
Trisomy 18: 41 (23–65)
Trisomy 13: 0 (0–2)
908 (782–1,047) 1 (0–3) All: 174 (148–201)
Trisomy 21: 129 (106–152)
Trisomy 18: 24 (15–35)
Trisomy 13: 21 (13–31)
415,702
Acceptance of further testing after a positive result from traditional prenatal screening: 90% 29,488,926 (25,937,229–32,769,117) All: 231 (181–288)
Trisomy 21: 182 (140–234)
Trisomy 18: 49 (27–76)
Trisomy 13: 0 (0–2)
1,055 (920–1,210) 1 (0–4) All: 161 (135–188)
Trisomy 21: 117 (94–140)
Trisomy 18: 23 (13–34)
Trisomy 13: 21 (12–31)
758,384

Abbreviations: CrI, credible interval; N, number; NIPT, noninvasive prenatal screening.

Note: Numbers may appear inexact due to rounding.

a

Incremental cost per case detected for first-tier NIPT (see Table 18 for reference case results) versus second-tier NIPT (the present scenario).