Table 25:
Scenario Analysis Results, A Subgroup of Pregnant People 35 to 39 Years Olda
| Strategy | Total Costs (95% CrI), $ | Cases Detected (95% CrI), n | Diagnostic Tests Performed (95% CrI), n | Diagnostic-Procedure-Related Pregnancy Losses (95% CrI), n | Affected Live Births (95% CrI), n | Incremental Cost Per Case Detected, vs. Second-Tier NIPT, $ |
|---|---|---|---|---|---|---|
| Traditional prenatal screening | 5,540,080 (4,888,764–6,164,005) | All: 73 (52–98) Trisomy 21: 56 (38–77) Trisomy 18: 17 (7–29) Trisomy 13: 0 (0–2) |
653 (482–841) | 1 (0–4) | All: 87 (69–107) Trisomy 21: 65 (49–82) Trisomy 18: 12 (6–20) Trisomy 13: 10 (4–16) |
— |
| Second-tier NIPT | 5,398,917 (4,744,893–6,045,225) | All: 87 (64–114) Trisomy 21: 67 (46–91) Trisomy 18:20 (10–33) Trisomy 13: 0 (0–1) |
191 (159–225) | 0 (0–1) | All: 82 (65–100) Trisomy 21: 60 (46–76) Trisomy 18: 12 (6–19) Trisomy 13: 10 (4–17) |
— |
| First-tier NIPT | 12,257,869 (10,619,425–13,982,271) | All: 126 (98–162) Trisomy 21: 87 (64–117) Trisomy 18:31 (17–50) Trisomy 13: 9 (2–18) |
490 (423–564) | 1 (0–3) | All: 68 (52–85) Trisomy 21: 51 (38–67) Trisomy 18: 10 (4–16) Trisomy 13:7 (2–13) |
173,680 |
Abbreviations: CrI, credible interval; NIPT, noninvasive prenatal testing.
Note: Numbers may appear inexact due to rounding.
a
Average cohort size: 28,563 pregnant people.