Table 6:
NIPT Accuracy for Trisomies 21, 18, and 13 Versus Traditional Prenatal Screening
| Author, Year | Traditional Prenatal Screening Method | Traditional Trisomy 21 (95% CI) | NIPT Trisomy 21 (95% CI) | Traditional Trisomy 18 (95% CI) | NIPT Trisomy 18 (95% CI) | Traditional Trisomy 13 (95% CI) | NIPT Trisomy 13 (95% CI) |
|---|---|---|---|---|---|---|---|
| Bianchi et al, 201452 | First-trimester PAPP-A and total hCG or β-hCG Second-trimester α-fetoprotein, hCG, unconjugated estriol, inhibin-A, with or without NT |
Sensitivity: 100% (29.2%–100%) FPR: 3.6% (2.8%–4.6%) |
Sensitivity: 100% (47.8%–100%) FPR: 0.3% (0.1%–0.7%) |
Sensitivity: 100% (2.5%–100%) FPR: 0.6% (0.1%–0.3%) |
Sensitivity: 100% (15.8%–100%) FPR: 0.2% (0%–0.4%) |
Not reported | Sensitivity: 100% (20.7%–100%) FPR: 0.2% (0.1%–0.5%) |
| Langlois et al, 201754 | First-trimester PAPP-A, free β-hCG, NT First-trimester PAPP-A, second-trimester α-fetoprotein, hCG, unconjugated estriol, inhibin-A, with or without NT |
Sensitivity: 83% (36%–99%) FPR: 5.4% (4.2%–6.9%) |
Sensitivity: 100% (54%–100%) FPR: 0% (0%–0.3%) |
Not reported | Not reported | Not reported | Not reported |
| Norton et al, 201556 | PAPP-A, total hCG or β-hCG, NT | Sensitivity: 78.9% (62.7%–90.4%) FPR: 5.4% (5.1%–5.8%) |
Sensitivity: 100% (90.7%–100%) FPR: 0.06% (0.03%–0.11%) |
Sensitivity: 80.0% (44.4%–97.5%) FPR: 0% (0%–0.1%) |
Sensitivity: 90% (55.5%–99.7%) FPR: 0.3% (0.2%–0.4%) |
Sensitivity: 50% (1.2%–98.7%) FPR: 0.3% (0.2%–0.4%) |
Sensitivity: 100% (15.8%–100%) FPR: 0% (0%–0.1%) |
| Quezada et al, 201558 | PAPP-A, β-hCG, fetal crown-rump length, NT | Sensitivity: 100% (93%–100%) FPR: 4% (4%–5%) |
Sensitivity: 100% (89.3%–100%) FPR: 0.1% (0%–0.2%) |
Sensitivity: 100% (93%–100%) FPR: 4% (4%–5%) |
Sensitivity: 90% (59.6%–98.2%) FPR: 0.2% (0.1%–0.4%) |
Sensitivity: 100% (93%–100%) FPR: 4% (4%–5%) |
Sensitivity: 40% (11.8%–76.9%) FPR: 0.1% (0%–0.1%) |
| Song et al, 201359 | Second-trimester α-fetoprotein, free β-hCG, unconjugated estriol | Sensitivity: 55% (23%–83%)a FPR: 14% (12%–16%) |
Sensitivity: 100% (59.8%–100%) FPR: 0% (0%–0.3%) |
Sensitivity: 55% (23%–83%)a FPR: 14% (12%–16%) |
Sensitivity: 100% (19.8%–100%) FPR: 0.1% (0.1%–0.4%) |
Sensitivity: 55% (23%–83%)a FPR: 14% (12%–16%) |
Sensitivity: 100% (5.5%–100%) FPR: 0% (0%–0.3%) |
Abbreviations: CI, confidence interval; FPR, false-positive rate; hCG, human chorionic gonadotropin; NIPT, noninvasive prenatal testing; NT, nuchal translucency; PAPP-A, pregnancy-associated plasma protein A.
a
Combined test accuracy for trisomy 21, 18, and 13.