Table 8:

Health Care Providers’ Understanding of NIPT

Author, Year, Country	Health Care Providers	Understanding of NIPT
Brewer et al, 2016,60 United States	Obstetricians	85.4% said that NIPT was a screening test for fetal aneuploidy; 14.6% said that it was a diagnostic test 40.8% said they would recommend diagnostic testing for fetal aneuploidy for all 23 chromosomes; 46.6% said they would recommend NIPT 92.2% agreed that the sensitivity of NIPT is better than traditional prenatal screening for trisomy 21 81.5% agreed that NIPT performs well, regardless of age or risk, and should be offered as a screening option for any pregnant person, regardless of age or risk status
Filoche et al, 2017,61 New Zealand	Obstetricians	35.2% felt “very confident” in offering NIPT for fetal aneuploidy; 40.6% felt “quite confident” 30.7% felt “very confident” in explaining positive predictive value 23.6% felt “very confident” in explaining fetal fraction
Haymon et al, 2014,{Haymon, 2014 #947} United States	Maternal–fetal medicine specialists	86.7% said that NIPT is being offered as a screening test in their practice; 13.3% said that NIPT was being offered as a diagnostic test 91.1% felt confident with knowledge of NIPT
Mayes et al, 2016,63 United States	Obstetricians	75% were aware of expanded NIPT options (testing for additional trisomies and microdeletion syndromes) 50% told patients that the accuracy of the expanded testing option is 99% to 100%; 25% said 90% to 98% 34% who did not order expanded NIPT would feel at least somewhat comfortable explaining the testing to patients; 83% of those who did order expanded NIPT would feel at least somewhat comfortable 14% who did not order expanded NIPT identified it as a diagnostic test; 33% who did order expanded NIPT identified it as a diagnostic test 41% who felt comfortable explaining expanded NIPT agreed that its clinical utility and validity has been established; only 7% who were not comfortable explaining expanded NIPT agreed that its clinical utility and validity has been established
Musci et al, 2013,64 United States	Obstetricians	32% already included NIPT in their practice; 22% were familiar with the published literature but had not yet ordered tests 39% had heard of the technology, but were less familiar with the data; 8% had never heard of NIPT
Sayres et al, 2011,65 United States	Mainly obstetricians but also nurses and nurse–midwives	85% reported a low level of knowledge about NIPT
Swaney et al, 2016,66 United States	Maternal–fetal medicine fellows	97.4% agreed that NIPT is screening test, not a diagnostic test 42.1% knew that the test was available for twins but could not identify which twin was carrying the aneuploidy; 48.2% were unaware of the possible use of NIPT in twins 81.9% knew that NIPT could be offered after 10 weeks’ gestation; 13.8% thought it could be offered at any time 63% were comfortable ordering NIPT without further education; 23% would not independently order the test based on their current knowledge level

Abbreviation: NIPT, noninvasive prenatal testing.