Table A5:
Risk of Biasa Among Nonrandomized Trials (ROBINS-I Tool)
| Preintervention | At Intervention | Postintervention | |||||
|---|---|---|---|---|---|---|---|
| Author, Year | Confounding | Study Participation Selection | Classification of Interventions | Deviations From Intended Intervention | Missing Data | Measurement of Outcomes | Selection of Reported Results |
| Bianchi et al, 201452 | Low | Moderatea | Low | Low | Moderateb | Low | Low |
| Langlois et al, 201754 | Low | Moderatea | Low | Low | Low | Low | Low |
| Palomaki et al, 201757 | Low | Moderatea | Low | Low | Moderateb | Seriousc | Moderated |
| Quezada et al, 201558 | Low | Moderatea | Low | Low | Moderateb | Moderatee | Low |
| Song et al, 201359 | Low | Moderatea | Low | Low | Low | Moderatee | Low |
Abbreviation: ROBINS-I, Risk of Bias in Non-randomized Studies–of Interventions.
a
Possible risk of bias levels: low, moderate, serious, critical, and no information.
a
Did not avoid inappropriate exclusions or had unclear consecutive or random enrolment of patients.
b
Missing data for some patients who did not have a successful noninvasive prenatal testing result.
c
Limited information regarding how clinical utility was measured among patients. Did not use a validated measurement tool.
d
Not all patients were included in the analysis.
e
Limited information regarding how clinical utility was measured among patients.