Table A7:

Ongoing Studies of Noninvasive Prenatal Testing

Registry	ID	Population	Country	Official Title	Condition(s)	Sponsor
ClinicalTrials.gov	NCT02424474	Average-risk	France	Fetal aneuploidies screening (21, 18, and 13) by cell-free fetal DNA analysis	Trisomies 21, 18, 13	Assistance Publique—Hôpitaux de Paris
Australian New Zealand Clinical Trials Registry	ACTRN12617001587392	Average-risk	Australia	Prenatal screening for aneuploidy in the Australian public hospital system: a noninvasive prenatal screening test (NIPT) feasibility study	Trisomies 21, 18, 13 Monosomy X	Nepean Hospital
ClinicalTrials.gov	NCT02787486	Average-risk and high-risk	United States	A clinical study to evaluate the relative clinical sensitivity, specificity, and performance of a laboratory-developed test as a screening test for fetal chromosomal aneuploidy, infectious and other diseases, and RhD genotyping in the general population of pregnant people	Trisomies 21, 18, 13 Sex chromosome aneuploidies	Progenity, Inc.
ClinicalTrials.gov	NCT03200041	Average-risk and high-risk	United Kingdom	Clinical evaluation of the IONA test for noninvasive prenatal screening in twin pregnancies	Trisomies 21, 18, 13	Premaitha Health
Chinese Clinical Trial Registry	ChiCTR-DDD-17013213	Average-risk and high-risk	China	The value of noninvasive prenatal testing in pregnancies of Hebei province: a prospective multi-center study	Trisomies 21, 18, 13	Second Hospital of Hebei Medical University
ClinicalTrials.gov	NCT02381457	General pregnant population	United States	SNP-based microdeletion and aneuploidy registry	Trisomies 21, 18, 13 Sex chromosome aneuploidies Microdeletion syndromes	Natera, Inc.
UMIN Clinical Trials Registry	UMIN000023935	Pregnant people (risk not specified)	Japan	Analysis of state-trait anxiety in clients of noninvasive prenatal testing: an investigation to improve the quality of genetic counselling	Not specified	Niigata University Hospital

Abbreviation: RhD, rhesus D antigen; SNP, single nucleotide polymorphism.