Table A8:
Assessment of the Applicability of Studies on the Cost-Effectiveness of NIPT
| Objective: To assess the cost-effectiveness of NIPT | |||||
|---|---|---|---|---|---|
| Author, Year | Is the study population similar to the question? | Are the interventions similar to the question? | Is the health care system in which the study was conducted sufficiently similar to the current Ontario context? | Were the perspectives clearly stated and what were they? | Are estimates of relative treatment effect from the best available source? |
| Nshimyumukiza et al, 201874 | Partially | Partially | Yes (Quebec, Canada) | Yes; public payer | Yes |
| Huang et al, 201775 | Partially | Yes | Yes (Ontario, Canada) | Yes; public payer | Yes |
| Maxwell et al, 201776 | Partially | Partially | Yes (Australia) | Yes; public payer | Yes |
| Colosi et al 201777 | Partially | Partially | Yes (Italy) | Yes; health care perspective | NA |
| Chitty et al, 201678 | Partially | Partially | Yes (United Kingdom) | Yes; United Kingdom National Screening Committee | Yes |
| Fairbrother et al 201679 | Partially | Partially | No (United States) | No | Yes |
| Author, Year | Are all future costs and outcomes discounted? (If yes, at what rate?) | Is the value of health effects expressed in terms of quality-adjusted life-years? | Are costs and outcomes from other sectors fully and appropriately measured and valued? | Overall judgment (directly applicable/partially applicable/not applicable) |
|---|---|---|---|---|
| Nshimyumukiza et al, 201874 | NA | No | No | Partially applicable |
| Huang et al, 201775 | NA | No | No | Partially applicable |
| Maxwell et al, 201776 | NA | No | No | Partially applicable |
| Colosi et al 201777 | NA | No | No | Partially applicable |
| Chitty et al, 201678 | NA | No | No | Partially applicable |
| Fairbrother et al 201679 | Unclear | No | Unclear | Not applicable |
Note: Response options for all items were “yes,” “partially,” “no,” “unclear,” and “NA” (not applicable).