Author response image 1. Supplementing CGA rescued the defective β-cell function in both the core and the mantle of the islet in 72 hpf cloche mutants.

(A-B) In Tg (ins:Rcamp1.07); cloche mutants at 72 hpf, supplementing CGA significantly rescued the number (A) and the maximal Ca²⁺ influx (B) of glucose-responsive β-cells both in the islet core and in the islet mantle. *P < 0.05, **P < 0.01; ns, not significant.