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. 2019 Jan 29;8:e41540. doi: 10.7554/eLife.41540

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© 2019, Zhao et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Author response image 5. — (A-B) In 60 hpf Tg (ins:Rcamp1.07) embryos, not acute/short-term, but only long-term incubation with calcineurin/NFAT inhibitors significantly reduced the number (A) and the maximal Ca²⁺ influx (B) of high glucose-responsive β-cells. After drug removal, the Ca²⁺ influx of some cells was recovered faster than the number of the glucose-responsive β-cells. *P < 0.05, **P < 0.01.