Table.

The Baseline Patient Characteristics.

Variable		SNRI n=27		SSRI n=25
Sex, n (%)
Male		14 (51.9)		13 (52.0)
Female		13 (48.1)		12 (48.0)
Age (y)
Mean (SD)		70.3 (8.4)		72.4 (8.4)
Median (range)		70.0 (49-82)		72.0 (57-86)
Age category, n (%)
≥ 40 years,<50 years		1 (3.7)		0
≥ 50 years,<60 years		1 (3.7)		1 (4.0)
≥ 60 years		25 (92.6)		24 (96.0)
Duration of Parkinson’s disease (y)
Mean (SD)		4.6 (4.7)		4.3 (3.7)
Median (range)		3.0 (0-20)		3.0 (1-14)
Treatment for Parkinson’s disease, n (%)a		27 (100)		25 (100)
Levodopa		26 (96.3)		20 (80.0)
Zonisamide		8 (29.6)		6 (24.0)
Pramipexole		5 (18.5)		4 (16.0)
Ropinirole		4 (14.8)		6 (24.0)
UPDRS II
Mean (SD)		13.5 (10.9)		11.7 (5.3)
Median (range)		12.0 (4-62)		11.0 (3-24)
UPDRS III
Mean (SD)		26.0 (11.6)		28.0 (14.4)
Median (range)		22.0 (11-55)		26.0 (2-68)
QIDS-J
Mean (SD)		11.3 (4.0)		10.9 (4.1)
Median (range)		11.0 (6-20)		10.0 (6-20)
QIDS-J severity category, n (%)
Mild (≥ 6, ≤ 10)		13 (48.1)		15 (60.0)
Moderate (≥ 11, ≤ 15)		9 (33.3)		5 (20.0)
Severe (≥ 16, ≤ 20)		5 (18.5)		5 (20.0)
Very severe (≥ 16, ≤ 20)		0		0
Apathy Scale score
Mean (SD)		19.3 (5.8)		18.8 (7.9)
Median (range)		21.0 (3-28)		19.0 (6-41)
Apathy Scale score category, n (%)
<10		2 (7.4)		3 (12.0)
≥ 10,<20		8 (29.6)		10 (40.0)
≥ 20,<30		17 (63.0)		10 (40.0)
≥ 30,<40		0		1 (4.0)
≥ 40		0		1 (4.0)
FOG-Q score
Mean (SD)		9.8 (5.8)		9.5 (4.6)
Median (range)		10.0 (0-20)		9.0 (0-20)

FOG-Q: Freezing of Gait Questionnaire, QIDS-J: Quick Inventory of Depressive Symptomatology Japanese version, SD: standard deviation, SNRI: serotonin norepinephrine reuptake inhibitor, SSRI: selective serotonin reuptake inhibitor, UPDRS: Unified Parkinson’s Disease Rating Scale

^aPatients could receive more than 1 treatment for Parkinson’s disease.