Table 1.
Characteristics of the Cohort of Persons Cytogenetically Diagnosed With Balanced Robertsonian Translocations, Great Britain, 1962–2006
| Characteristic | No. of Persons | % | Person-Years |
|---|---|---|---|
| Sex | |||
| Male | 807 | 40.6 | 19,355 |
| Female | 1,180 | 59.4 | 28,544 |
| Age at diagnosis, years | |||
| 0–4 | 240 | 12.1 | 6,306 |
| 5–14 | 110 | 5.5 | 3,284 |
| 15–24 | 318 | 16.0 | 8,489 |
| 25–34 | 612 | 30.8 | 15,033 |
| 35–44 | 333 | 16.8 | 7,831 |
| 45–64 | 289 | 14.5 | 6,038 |
| 65–84 | 85 | 4.3 | 918 |
| Year of diagnosis | |||
| 1962–1969 | 121 | 6.1 | 4,064 |
| 1970–1979 | 181 | 9.1 | 6,351 |
| 1980–1989 | 445 | 22.4 | 12,315 |
| 1990–2006 | 1,240 | 62.4 | 25,169 |
| Year of birth | |||
| Before 1950 | 544 | 27.4 | 12,926 |
| 1950–1969 | 935 | 47.1 | 23,079 |
| 1970–1989 | 378 | 19.0 | 9,302 |
| 1990–2005 | 130 | 6.5 | 2,592 |
| Chromosomes involved | |||
| 13;13 | 2 | 0.1 | 58 |
| 13;14 | 1,248 | 62.8 | 29,967 |
| 13;15 | 55 | 2.8 | 1,225 |
| 13;21 | 20 | 1.0 | 490 |
| 13;22 | 20 | 1.0 | 483 |
| 14;14 | 5 | 0.3 | 100 |
| 14;15 | 52 | 2.6 | 1,129 |
| 14;21 | 390 | 19.6 | 9,438 |
| 14;22 | 57 | 2.9 | 1,303 |
| 15;15 | 2 | 0.1 | 35 |
| 15;21 | 35 | 1.8 | 816 |
| 15;22 | 35 | 1.8 | 942 |
| 21;21 | 6 | 0.3 | 179 |
| 21;22 | 38 | 1.9 | 1,101 |
| 22;22 | 10 | 0.5 | 277 |
| Othera | 12 | 0.6 | 356 |
| Total | 1,987 | 100.0 | 47,899 |
a Including 7 robertsonian translocations between 2 D-group chromosomes, 4 between a D- and G-group chromosome, and 1 patient mosaic for 2 different robertsonian translocations.