Table 2.

Cause-Specific Mortality Among 1,987 Persons Cytogenetically Diagnosed With Balanced Robertsonian Translocations, Great Britain, 1962–2006

ICD-9 Code	Cause	No. of Deaths	SMR	95% CI	AERa
140–208	All malignant neoplasms	81	0.88	0.70, 1.10	−22.5
240–279	Endocrine, nutritional, metabolic, immunity	3	0.71	0.15, 2.07	−2.6
290–319	Mental disorders	4	0.70	0.19, 1.80	−3.5
320–389	Diseases of the nervous system	12	1.57	0.81, 2.75	9.1
390–459	Diseases of the circulatory system	83	0.86	0.69, 1.07	−28.4
410–414	Ischemic heart disease	42	0.77	0.55, 1.04	−26.4
410	Acute myocardial infarction	29	0.91	0.61, 1.30	−6.3
420–429	Other heart disease	8	1.01	0.44, 1.99	0.20
430–437	Cerebrovascular disease	20	0.93	0.57, 1.43	−3.2
460–519	Diseases of the respiratory system	30	1.01	0.68, 1.44	0.70
480–486	Pneumonia	11	1.11	0.55, 1.98	2.2
490–494, 496	Chronic lower respiratory disease	10	0.67	0.32, 1.24	−10.2
520–579	Diseases of the digestive system	13	0.90	0.48, 1.53	−3.1
570–572, 573.0, 573.3–573.9	Liver disease	7	1.05	0.42, 2.17	0.71
580–629	Diseases of the genitourinary system	3	0.89	0.18, 2.59	−0.80
710–739	Musculoskeletal system and connective tissue	1	0.63	0.02, 3.48	−1.30
740–759	Congenital anomalies	5	4.72b	1.53, 11.0	8.2
800–999	Accidents and violence	14	0.96	0.52, 1.60	−1.33
001–999	All causesc	257	0.92	0.81, 1.04	−44.5

Abbreviations: AER, absolute excess rate; CI, confidence interval; ICD-9, International Classification of Diseases, Ninth Revision; SMR, standardized mortality ratio.

^a Number of excess deaths per 100,000 population per annum.

^b Two-sided P value based on exact method; P < 0.01.

^c Includes 8 deaths from causes not listed individually in the table (4 unknown, 2 senility, 1 infarction of spleen, and 1 myelodysplastic syndrome).