. 2018 Dec 7;188(3):500–508. doi: 10.1093/aje/kwy266

Table 3.

Cause-Specific Mortality Among 1,987 Persons Cytogenetically Diagnosed With Balanced Robertsonian Translocations, According to Age at Cytogenetic Diagnosis, Great Britain, 1962–2006

ICD-9 Code	Cause	Age at Cytogenetic Diagnosis, years
		0–14			15–44			45–84
		No. of Deaths	SMR	95% CI	No. of Deaths	SMR	95% CI	No. of Deaths	SMR	95% CI
140–208	All malignant neoplasms	0	0.00	0.0, 3.08	34	0.96	0.67, 1.34	47	0.85	0.63, 1.13
240–279	Endocrine, nutritional, metabolic, immunity	0	0.0	0.0, 22.5	1	0.63	0.02, 3.52	2	0.80	0.10, 2.90
290–319	Mental disorders	0	0.0	0.0, 13.5	2	1.06	0.13, 3.82	2	0.57	0.07, 2.05
320–389	Diseases of the nervous system	4	11.9^a	3.25, 30.5	4	1.31	0.36, 3.34	4	0.95	0.26, 2.43
390–459	Diseases of the circulatory system	0	0.0	0.0, 5.03	28	1.18	0.78, 1.70	55	0.76^b	0.58, 0.99
460–519	Diseases of the respiratory system	1	2.83	0.07, 15.8	9	1.25	0.57, 2.37	20	0.91	0.56, 1.40
520–579	Diseases of the digestive system	1	2.50	0.06, 13.9	6	0.84	0.31, 1.83	6	0.86	0.32, 1.88
580–629	Diseases of the genitourinary system	0	0.0	0.0, 103.9	1	1.19	0.03, 6.64	2	0.80	0.10, 2.88
710–739	Musculoskeletal system and connective tissue	0	0.0	0.0, 141.0	1	1.97	0.05, 11.0	0	0.0	0.0, 3.46
740–759	Congenital anomalies	5	14.6^a	4.74, 34.1	0	0.0	0.0, 6.93	0	0.0	0.0, 19.9
800–999	Accidents and violence	1	0.48	0.01, 2.65	10	1.11	0.53, 2.05	3	0.84	0.17, 2.47
001–999	All causes^c	14	2.00^b	1.09, 3.35	99	1.06	0.86, 1.28	144	0.81^b	0.68, 0.95

Abbreviations: CI, confidence interval; ICD-9, International Classification of Diseases, Ninth Revision; SMR, standardized mortality ratio.

^a Two-sided P value based on exact method; P < 0.001.

^b Two-sided P value based on exact method; P < 0.05.

^c Includes 8 deaths from causes not listed individually in the table (4 unknown, 2 senility, 1 infarction of spleen, and 1 myelodysplastic syndrome).