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. 2018 Nov 29;188(3):579–586. doi: 10.1093/aje/kwy261

Table 2.

Estimated Riska of All-Cause Mortality Under Several Hypothetical Physical Activity Strategiesb Among Men With Nonmetastatic Prostate Cancer, Health Professionals Follow-up Study, 2000–2014

Strategy 10-Year Risk, %c 95% CI Risk Ratio 95% CI Risk Difference, % 95% CI
No intervention 15.4 13.7, 17.4 1.00 Referent 0 Referent
Vigorous activity, hours/week
 ≥1.25 13.0 10.9, 15.4 0.84 0.75, 0.94 −2.4 −3.9, −0.9
 ≥2.50 11.1 8.7, 14.1 0.72 0.58, 0.88 −4.3 −6.6, −1.8
 ≥3.75 10.5 8.0, 13.5 0.68 0.53, 0.85 −5.0 −7.3, −2.3
Moderate activity, hours/week
 ≥2.50 13.9 12.0, 16.0 0.90 0.84, 0.94 −1.6 −2.4, −0.9
 ≥5.00 12.6 10.6, 14.7 0.81 0.73, 0.88 −2.9 −4.2, −1.8
 ≥7.50 12.2 10.3, 14.4 0.79 0.71, 0.86 −3.2 −4.5, −2.1

Abbreviation: CI, confidence interval.

a Estimates were based on the parametric g-formula, adjusted for age, parental history of myocardial infarction, primary treatment, clinical stage at diagnosis, Gleason grade at diagnosis, prostate-specific antigen level at diagnosis, smoking history, body mass index, vigorous and moderate physical activity, and the development of functional impairment, metastasis, myocardial infarction, stroke, congestive heart failure, or amyotrophic lateral sclerosis.

b All strategies excused men from following the recommended physical activity levels after development of functional impairment, metastasis, myocardial infarction, stroke, congestive heart failure, or amyotrophic lateral sclerosis.

c The observed risk was 15.4%. There were 250 observed deaths among 2,299 men over 8,972 person-years of follow-up. Risk under no intervention (i.e., the natural course) was the referent.