Table 6.
Associations of genotypes and allele frequencies of MMP-2 -1306, -790, and -735, MMP-9 -1562 and TIMP-2 -418 genes, and AgP risks in nonalcohol-drinking participants using logistic regression analysis.
| Genotype | HC n = 87 (%) |
AgP n = 40 (%) |
Crude OR (95% CI) |
Adjusted ORa (95% CI) |
|---|---|---|---|---|
| MMP-2-1306 | ||||
| CT/TT | 7 (8.0) | 3 (7.5) | 1.00 | 1.00 |
| CC | 80 (92.0) | 37 (92.5) | 1.08 (0.26–4.41) | 0.88 (0.19–3.98) |
| T allele | 7 (4.1) | 3 (3.7) | 1.00 | 1.00 |
| C allele | 165 (95.9) | 77 (96.3) | 1.08 (0.27–4.27) | 0.86 (0.20–3.72) |
| MMP-2-735 | ||||
| TT | 9 (10.4) | 2 (5.0) | 1.00 | 1.00 |
| CT | 31 (35.6) | 15 (37.5) | 2.18 (0.42–11.36) | 1.96 (0.34–11.30) |
| CC | 47 (54.0) | 23 (57.5) | 2.20 (0.44–11.03) | 2.06 (0.38–11.26) |
| T allele | 49 (28.5) | 19 (23.7) | 1.00 | 1.00 |
| C allele | 123 (71.5) | 61 (76.3) | 1.26 (0.68–2.32) | 1.26 (0.65–2.43) |
| MMP-2-790 | ||||
| GT/GG | 12 (13.8) | 9 (22.5) | 1.00 | 1.00 |
| TT | 75 (86.2) | 31 (77.5) | 0.55 (0.21–1.44) | 0.63 (0.23–1.75) |
| G allele | 13 (7.6) | 9 (11.2) | 1.00 | 1.00 |
| T allele | 159 (92.4) | 71 (88.8) | 0.64 (0.26–1.56) | 0.69 (0.27–1.79) |
| TIMP-2-418 | ||||
| GC/CC | 32 (36.8) | 11 (27.5) | 1.00 | 1.00 |
| GG | 55 (63.2) | 29 (72.5) | 1.53 (0.68–3.48) | 1.73 (0.71–4.22) |
| G allele | 140 (82.4) | 68 (85.0) | 1.00 | 1.00 |
| C allele | 30 (17.6) | 12 (15.0) | 0.80 (0.39–1.66) | 0.72 (0.33–1.56) |
| MMP-9-1562 | ||||
| CT/TT | 18 (20.7) | 14 (35.0) | 1.00 | 1.00 |
| CC | 69 (79.3) | 26 (65.0) | 0.48 (0.21–1.11) | 0.40 (0.16–1.02) |
| T allele | 19 (11.0) | 16 (20.0) | 1.00 | 1.00 |
| C allele | 153 (89.0) | 64 (80.0) | 0.49 (0.24–1.01) | 0.40* (0.18–0.90) |
* P < 0.05.
AgP = aggressive periodontitis group; CI = confidence interval; HC = healthy control group; MMP = matrix metalloproteinase; OR = odds ratio; TIMP, tissue inhibitor of MMPs.
a
Adjustment for age, sex, and habits of betel-quid chewing and smoking.