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. 2017 Feb 11;12(1):83–90. doi: 10.1016/j.jds.2016.12.001

Figure 2.

Figure 2

Histological changes in the drug-induced groups after 7 days. (A) Bright view of the type I collagen group showing the temporomandibular joint (TMJ) structure. (B) Sagittal view of the TMJ of the type I collagen group. (C) Enlarged view of the TMJ disc in the type I collagen group showing the regular thickness and some chondrocyte cells (black arrows). (D) Enlarged view of the TMJ condyle subchondral bone separated into four layers in type I collagen group. (E) Bright view of the complete Freund's adjuvant (CFA)-induced arthritis group showing inflamed cysts. (F) Sagittal view of the TMJ in the CFA-induced arthritis group. (G) Enlarged view of the TMJ disc in the CFA-induced arthritis group. (H) Enlarged view of the TMJ condyle subchondral bone in the CFA-induced arthritis group for investigation of bone changes in the adaptive transition zone. (I) Bright view of the collagen-induced arthritis (CIA) group showing severely inflamed cysts. (J) Sagittal view of the TMJ in the CIA group. (K) Enlarged view of the TMJ disc in the CIA group. Although the TMJ disc thickness was maintained, the chondrocyte cells disappeared (black arrows). (L) Enlarged view of the TMJ condyle subchondral bone in the CIA group. The TMJ condyle subchondral bone appeared unclearly stratified and severely degraded in the hypertrophic zone. Scale bar for (B), (F), and (J) is 200 μm. Scale bar for (C), (D), (G), (H), (K) and (L) is 25 μm.