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Flowchart for the assessment of human proteome cross-matching and missense mutation hemophilia A inhibitor risk. The flowchart shows the process by which the presence, or otherwise, of a novel peptide-MHC surface is determined given a specific combination of endogenous F8 missense mutation and human leukocyte antigen isoform. tFVIII: therapeutic factor VIII; FVIII: factor VIII; TCR: T-cell receptor.
