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. 2018 Sep 28;104(3):599–608. doi: 10.3324/haematol.2018.195669

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Figure 4. — A proteome cross-matching example: Arg593Cys for HLA-DRB1*0101. This example concerns the two tFVIII binding cores from Figure 3, IQRFLPNPA and YLTENIQRF. (A) Both cores cross-match to 9-mers from proteins in the human proteome at TCR-facing positions 2, 3, 5, 7 and 9. (B) Both of the matched 9-mers (one each from tubulin polyglutamylase and C2orf48, but none from dysbindin) are predicted by NetMHCII to form binding cores within 15-mers derived from these proteins. Hence, we conclude that the F8 missense mutation/HLA isoform combination Arg593Cys/HLA-DRB1*0101 is associated with negligible risk of inhibitor formation. FVIII: factor VIII; tFVIII: therapeutic factor VIII; TCR: T-cell receptor; HLA: human leukocyte antigen.