Table 4.
Genotype distribution of VDR SNPs in periodontitis patients and healthy controls.
| Genotype | HC n = 163 |
AgP n = 92 |
CP n = 385 |
||||||
|---|---|---|---|---|---|---|---|---|---|
| n (%) | n (%) | Adjusted ORa | 95% CI | p-Valueb | n (%) | Adjusted ORa | 95% CI | p-Valueb | |
| rs731236 (TaqI) | 0.11 | 0.05 | |||||||
| TT | 152 (93.3) | 81 (88.0) | 1 | Reference | 352 (91.4) | 1 | Reference | ||
| Tt | 9 (5.5) | 11 (12.0) | 2.29 | 0.91–5.76 | 0.07 | 33 (8.6) | 1.58 | 0.74–3.39 | 0.23 |
| tt | 2 (1.2) | 0 (0) | 0 | 0.30 | 0 (0) | 0 | 0.03 | ||
| MAF (%) | 4.0 | 6.0 | 1.53 | 0.66–3.45 | 0.31 | 4.3 | 0.93 | 0.47–1.75 | 0.82 |
| Tt/ttc | 11 (6.8) | 11 (12.0) | 0.86 | 0.24–3.05 | 0.82 | 33 (8.6) | 1.43 | 0.72–3.07 | 0.33 |
| rs7975232 (ApaI) | 0.48 | 0.28 | |||||||
| aa | 80 (49.1) | 41 (44.6) | 1 | Reference | 177 (46.0) | 1 | Reference | ||
| Aa | 72 (44.2) | 41 (44.6) | 1.11 | 0.65–1.90 | 0.70 | 165 (42.9) | 1.04 | 0.71–1.52 | 0.86 |
| AA | 11 (6.7) | 10 (10.8) | 1.77 | 0.70–4.52 | 0.23 | 43 (11.1) | 1.77 | 0.87–3.60 | 0.11 |
| MAF (%) | 28.8 | 33.2 | 1.22 | 0.83–1.80 | 0.31 | 32.6 | 1.19 | 0.90–1.59 | 0.22 |
| Aa/AAc | 83 (50.9) | 51 (55.4) | 1.21 | 0.40–1.69 | 0.60 | 208 (54.0) | 1.13 | 0.77–1.66 | 0.52 |
| rs1544410 (BsmI) | 0.07 | 0.04 | |||||||
| bb | 115 (70.5) | 75 (81.5) | 1 | Reference | 308 (80.0) | 1 | Reference | ||
| Bb | 43 (26.4) | 13 (14.1) | 0.46 | 0.23–0.92 | 0.03 | 72 (18.7) | 0.63 | 0.40–0.97 | 0.03 |
| BB | 5 (3.1) | 4 (4.4) | 1.23 | 0.32–4.72 | 0.77 | 5 (1.3) | 0.37 | 0.11–1.31 | 0.11 |
| MAF (%) | 16.3 | 11.4 | 0.66 | 0.38–1.13 | 0.14 | 10.6 | 0.61 | 0.42–0.90 | 0.01 |
| Bb/BBc | 48 (29.5) | 17 (18.5) | 0.33 | 0.13–0.79 | 0.02 | 77 (20.0) | 0.58 | 0.38–0.90 | 0.01 |
| rs2228570 (FokI) | 0.007 | 0.23 | |||||||
| FF | 43 (26.4) | 42 (45.6) | 1 | Reference | 104 (27.0) | 1 | Reference | ||
| Ff | 76 (46.6) | 33 (35.9) | 0.44 | 0.25–0.80 | 0.007 | 202 (52.5) | 1.10 | 0.71–1.71 | 0.68 |
| ff | 44 (27.0) | 17 (18.5) | 0.40 | 0.20–0.80 | 0.009 | 79 (20.5) | 0.74 | 0.44–1.24 | 0.25 |
| MAF (%) | 50.3 | 36.4 | 0.57 | 0.39–0.82 | 0.003 | 46.8 | 0.87 | 0.67–1.12 | 0.28 |
| Ff/ffc | 120 (73.6) | 50 (54.4) | 0.48 | 0.23–0.99 | 0.048 | 281 (73.0) | 0.95 | 0.62–1.45 | 0.82 |
AgP: aggressive periodontitis; CP: chronic periodontitis; HC: healthy controls; MAF: minimal allelic frequency; OR: odds ratio; CI: confidence interval.
a
Adjusted for gender, age and smoking status for logistic regression analysis.
b
p < 0.006 was accepted as significant for multiple testing corrected by Bonferroni method.
c
t carrier, A carrier, B carrier or f carrier versus each reference.