Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 22;10:146. doi: 10.3389/fphar.2019.00146

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Burghi, Echeverría, Sosa, Quiroga, Muñoz, Davio, Monczor, Fernández and Dominici.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Proposed MasR signaling mechanisms. The MasR has constitutive activity toward reduction of cAMP levels. This effect is mediated by receptor coupling to Gαi adenylyl cyclase signaling pathway. MasR putative ligands [Ang-(1–7) and AVE 0991] amplify MasR activity. In addition to modulation of cAMP, the MasR attenuates Ang-(1–7)-induced ERK1/2 phosphorylation mediated by AT1R.