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Tendon responses to loading, unloading, ageing and injury: arrows indicate the overall direction
| Cellular/molecular | Structural/mechanical | ||||
|---|---|---|---|---|---|
| Anabolic/catabolic | Cell number | Tissue synthesis | CSA | Stiffness | |
| Loading | ↑ | → | ↑ | ↑ | ↑ |
| Unloading | ↓ | → | ↓ | → | ↓ |
| Ageing | →↘ | ↓* | → | → | →↘ |
| Injury | ↑ | ↓ | ↑ | ↑ | →↘** |
*Only animal data. **Only tendinopathy.
