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. 2019 Feb 22;13:137. doi: 10.3389/fnins.2019.00137

FIGURE 1.

FIGURE 1

Quantification of interneuron numbers in hippocampal layers of wild type (wt) and hAPP-transgenic Tg2576 mice (tg). In panel (A) typical staining patterns of parvalbumin-, calbindin-, calretinin-, somatostatin-, and hAPP-immunoreactive neurons are depicted in wt and tg mouse hippocampus. Note the similar labeling intensity in wt and tg brain sections for all antigens except hAPP. The hippocampal layers analyzed are indicated in the wt pan-neuronal labeling image (Neurons). In panels B–E, the proportions of parvalbumin-, calbindin-, calretinin-, and somatostatin-positive neurons in hippocampal layers of wt and tg mice are quantified. Total neuronal numbers in each layer (hilus 69.8 ± 2.8; S. mol 48.2 ± 6.7; S. lac. 68.5 ± 8.5; S. rad. 407.2 ± 49.0; S. ori. 269.5 ± 13.0) were set to 100%. Note the similar interneuron proportions in wt and tg hippocampus for most data analyzed. ∗significantly different from wild type (p < 0.05; unpaired t test).