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. 2019 Feb 22;13:137. doi: 10.3389/fnins.2019.00137

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Copyright © 2019 Höfling, Shehabi, Kuhn, Lichtenthaler, Hartlage-Rübsamen and Roßner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantitative analyses of the co-localization between somatostatin-immunoreactive neurons and hAPP-expressing interneurons in hippocampus of Tg2576 mice. Typical examples of double labelings in stratum oriens are shown in panel (A). White arrows point to double-labeled neurons, green, and red arrows to neurons that are only labeled by green (somatostatin) and red (hAPP) fluorescence, respectively. Quantitative analysis revealed that of all hAPP transgene-expressing interneurons 1 to 2% in stratum moleculare and stratum lacunosum moleculare to approximately 30% (in DG hilus and stratum oriens) were somatostatin- immunoreactive (B). Of all somatostatin-expressing neurons, 30 to 76% expressed the hAPP transgene in all hippocampal layers (C).