FIGURE 6.

In this Figure, the proportion of hAPP-positive hippocampal interneurons co-expressing parvalbumin, calbindin, calretinin, and somatostatin is summed up in individual hippocampal layers. In stratum moleculare and stratum lacunosum moleculare less than 10% of all hAPP-expressing neurons are immunoreactive for the four interneuron markers analyzed, whereas in stratum radiatum and DG hilus 40 to 50%, and in stratum oriens all hAPP-immunoreactive neurons are positive for these interneuron markers. Additionally, the contribution of individual interneuron types to the hAPP-expressing population varies considerably in hippocampal layers as indicated by the respective color.