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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Circ Res. 2019 Mar;124(5):737–746. doi: 10.1161/CIRCRESAHA.118.314350

Figure 8. Intercalated disc Nav1.5 macromolecular signaling complex.

Figure 8.

Via direct interaction of Nav1.5 with ankyrin-G and βIV spectrin, CaMKIIδ resides in close proximity with its target molecule, Nav1.5. Our new findings implicate ankyrin-G in targeting the PP2A complex via B56α to the Nav1.5 intercalated disc complex to balance CaMKII-dependent phosphorylation. Together, CaMKIIδ and PP2A regulate INa,L in heart.